tokenpocketpei下载|kala
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2024-03-07 19:28:12
KALA | 多肽 | MCE
KALA | 多肽 | MCE
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Peptides
KALA
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KALA
目录号: HY-P2530
纯度: 96.09%
FAQs
Data Sheet
SDS
COA
产品使用指南
溶解度
摩尔计算器
动物溶解方案
KALA 是一种在生理 pH 下形成 α-螺旋结构的两亲性肽。KALA 修饰了包裹质粒 DNA 的脂质体膜，也可以用作融合肽，通过半乳糖实现有效的肝靶向和受体转染 DNA。
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务
Custom Peptide Synthesis
KALA Chemical Structure
CAS No. : 187987-64-0
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2. 同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内
可免费申领三个不同产品的试用装。
3. 试用装只面向终端客户。
规格
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数量
1 mg
￥2500
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0
1
2
3
4
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6
7
5 mg
￥7500
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1
2
3
4
5
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7
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KALA 相关抗体
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KALA 相关产品
•相关化合物库:
Bioactive Compound Library Plus
Peptide Library
•同靶点产品:
•同靶点蛋白产品:
生物活性
纯度 & 产品资料
参考文献
生物活性
KALA is an amphiphilic peptide that forms an α-helical structure at physiological pH. KALA modifies a plasmid DNA-encapsulating liposomal membrane and is used as a fusogenic peptide in order to achieve effective liver targeting and transfection of DNA via galactose receptors[1].
体外研究(In Vitro)
When a plasmid DNA-encapsulating liposomal membrane is modified with the KALA peptide, transgene expression and immune activation are facilitated in bone marrow-derived dendritic cells (BMDCs)[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
KALA 相关抗体:
Clinical Trial
分子量
3131.82
Formula
C144H248N40O35S
CAS 号
187987-64-0
性状
固体
颜色
White to off-white
Sequence
Trp-Glu-Ala-Lys-Leu-Ala-Lys-Ala-Leu-Ala-Lys-Ala-Leu-Ala-Lys-His-Leu-Ala-Lys-Ala-Leu-Ala-Lys-Ala-Leu-Lys-Ala-Cys-Glu-Ala
Sequence Shortening
WEAKLAKALAKALAKHLAKALAKALKACEA
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogen
Powder
-80°C
2 years
-20°C
1 year
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
In Vitro:
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
Contents
Assign value
Acidic amino acid
Asp (D), Glu (E), and the C-terminal -COOH.
-1
Basic amino acid
Arg (R), Lys (K), His (H), and the N-terminal -NH2
+1
Neutral amino acid
Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)
0
3. Recommended solution:
Overall charge of peptide
Details
Negative (<0)
1. Try to dissolve the peptide in water first.
2. If water fails, add NH4OH (<50 μL).
3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)
1. Try to dissolve the peptide in water first.
2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
纯度: 96.09%
选择批次：
HY-P2530-263485
Data Sheet (521 KB)
SDS (252 KB)
COA (256 KB)
RP-HPLC (111 KB)
MS (218 KB)
元素分析报告 (202 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Naoya Miura, et al. Identification and Evaluation of the Minimum Unit of a KALA Peptide Required for Gene Delivery and Immune Activation. J Pharm Sci. 2017 Oct;106(10):3113-3119.
[Content Brief]
[1]. Naoya Miura, et al. Identification and Evaluation of the Minimum Unit of a KALA Peptide Required for Gene Delivery and Immune Activation. J Pharm Sci. 2017 Oct;106(10):3113-3119.
摩尔计算器
稀释计算器
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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Help & FAQs
Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
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Keywords:
KALA187987-64-0OthersInhibitorinhibitorinhibit
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Ukulele – Kala Brand Music Co.™
Ukulele – Kala Brand Music Co.™
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Kala® Elite USA
The Kala Elite USA Series is designed and handmade at our shop in Petaluma, California. Every instrument is an individual, from the handpicked wood to the tiniest of structural pieces. We are proud to introduce this series to ukulele players across the world. From traditional Koa to classic Mahogany, each Elite USA ukulele is built with care.
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Solid Wood
Solid wood is, in essence, one solid piece of wood that makes up the entire soundboard of the instrument. It is the most resonate and pure form of the tonewood and requires much more finesse to install properly. However the wood is intended to sound with all its unique tones, it will be most apparent in a solid wood instrument. It is somewhat delicate in comparison to laminate wood but is highly sought after.
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Solid Top
The most crucial component to an instrument’s tone is the top of the instrument known as the sound board. The top of the instrument vibrates along with the strings to create greater projection that also shapes the tone. At Kala we have a robust selection of tonewood options that satisfy a huge variety of tonal preferences. Our solid top instruments are sought after for their excellent construction and beautiful sound.
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Crossover
The Crossover collection provides a wonderful variety of unique ukulele instruments that are sure to catch the eye and the ear. Consisting of models like the Kala Archtop, banjo ukulele, and vintage looking Kala Resonator - this category is perfect for the player looking to stand out from the rest of the crowd. If you’re ready for something new, something different, or just something traditional with a twist then check out this page.
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MAKALA®
Simply the best entry-level ukulele for over a decade. Kala is known for high-quality instruments that have amazing tone, and our Makala ukulele are no exception. Focusing on the essentials - quality at an affordable price - a Makala is the perfect uke to start on. With many color and design options, there is a Makala ukulele to fit any personality.
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Exotic Wood
Exotic woods offer unique tonal and aesthetic qualities not always found in more common tonewoods. These instruments are endowed with unique and beautiful grain patterns that provide nuance and a distinct musical experience. Due to the nature of complex grain patterns almost every exotic wood ukulele has a certain level of variance in its appearance that makes each ukulele one of a kind. Just take a look at the swirling patterns of our Bocote ukulele or the bright striking colors of the exotic mahogany line. If you find beauty in originality then this collection is for you!
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Traditional Mahogany
Mahogany is the great all-around tone wood. A sweet warm and woody sound, beautiful mid-ranged tone, and impressive projection make Mahogany one of the most popular choices for musicians of all types and a favorite of many of the Kala luthiers. Mahogany can range in color from light to darker brown coloring.
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The WATERMAN® & UKADELIC®
The Waterman and Ukadelic lines were updated and improved in 2017. They are both now included in the Kala line and all Ukadelics are now made of the same durable plastic as The Waterman. They are easy to clean and you can take them anywhere. They remain as affordable and versatile as ever—ready for any jam session or adventure.
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KALA-LTP-S
Kala Learn To Play Soprano Ukulele Starter Kit
-
$79
$75
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Kala Learn To Play Soprano Ukulele Starter Kit
KALALTPS2105
$79.00 MSRP
$75.00
Our classic beginner ukulele, the Kala Learn to Play Ukulele Starter Kit comes with everything you need to start playing today. This pack is perfe...
More Details →
KALA-LTP-MH
Mandy Harvey Learn To Play Signature Series Tenor Ukulele
-
$149
$139
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Mandy Harvey Learn To Play Signature Series Tenor Ukulele
KALALTPMH2006
$149.00 MSRP
$139.00
We are excited to announce the newest addition to our Learn To Play series—the Mandy Harvey Learn To Play Signature Series Tenor Ukulele!
Mandy is...
More Details →
KALA-LTP-CC-S
Kala Learn To Play Color Chord™ Ukulele Starter Kit
-
$49
$45
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Kala Learn To Play Color Chord™ Ukulele Starter Kit
KALA-LTP-CC-S
$49.00 MSRP
$45.00
Kala’s Color Chord Ukulele Starter Kit will have you playing songs right away! You’ll learn 4 Color Chords that will have you playing 100s of song...
More Details →
KA-15C
KA-15C Satin Mahogany Concert Ukulele
-
$99
$85
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KA-15C Satin Mahogany Concert Ukulele
KA15C2006
$99.00 MSRP
$85.00
The KA-15 Series is Kala’s flagship Mahogany collection and has become an industry standard. The traditional design is highlighted with a satin fin...
More Details →
MK-S
Makala Soprano Ukulele
-
$59
X
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Makala Soprano Ukulele
MKS2105
$59.00
MSRP
The Makala Classic line is simply the best entry-level ukulele on the market. Sound and playability usually suffer when offered at these affordab...
More Details →
KA-15S
KA-15S Satin Mahogany Soprano Ukulele
-
$69
$65
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KA-15S Satin Mahogany Soprano Ukulele
KA15S2006
$69.00 MSRP
$65.00
With so many ukulele options out there, how does one know what to choose? Kala, known for great quality, sound and affordability, has the best ent...
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MK-S/PACK
Makala Soprano Ukulele Pack
-
$89
$79
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Makala Soprano Ukulele Pack
MKSPACK2105
$89.00 MSRP
$79.00
The MK-S Pack includes a Makala Classic Soprano ukulele, clip-on tuner, gig bag, and instruction pamphlet. The Makala Classic Soprano ukulele is ...
More Details →
Out of Stock
KA-C
Satin Mahogany Concert Ukulele
-
$109
$99
X
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Out of Stock
Satin Mahogany Concert Ukulele
KAC2006
$109.00 MSRP
$99.00
This product is temporarily unavailable online.
The Satin Mahogany line is Kala’s flagship collection and has become an industry standard. The traditional design is highlighted with a satin fini...
More Details →
KA-MXMTOON-C
mxmtoon Signature Concert Ukulele
-
$109
$99
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mxmtoon Signature Concert Ukulele
KA-MXMTOON-C
$109.00 MSRP
$99.00
Songwriting maven mxmtoon has teamed up with Kala to create her very own signature ukulele!
Born and raised in Oakland, mxmtoon is a self-made sing...
More Details →
MK-C/PACK
Makala Concert Ukulele Pack
-
$109
$99
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Makala Concert Ukulele Pack
MKCPACK2105
$109.00 MSRP
$99.00
The MK-C Pack includes a Makala Classic Concert ukulele, clip-on tuner, gig bag, and instruction pamphlet. The Makala Classic Concert ukulele is ...
More Details →
Out of Stock
KA-S
Satin Mahogany Soprano Ukulele
-
$99
$89
X
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Out of Stock
Satin Mahogany Soprano Ukulele
KAS2006
$99.00 MSRP
$89.00
This product is temporarily unavailable online.
The Satin Mahogany line is Kala’s flagship collection and has become an industry standard. The traditional design is highlighted with a satin fini...
More Details →
KA-15S-BLK
Black Satin Mahogany Soprano Ukulele
-
$69
$65
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Black Satin Mahogany Soprano Ukulele
KA15SBLK2006
$69.00 MSRP
$65.00
The KA-15 Series is Kala’s flagship Mahogany collection and has become an industry standard. The traditional design is highlighted with a satin fin...
More Details →
KA-CG
Gloss Mahogany Concert Ukulele
-
$139
$129
X
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Gloss Mahogany Concert Ukulele
KACG2006
$139.00 MSRP
$129.00
The Gloss Mahogany line features a high-gloss finish to enhance the simple elegance of the Mahogany woodgrain. The gloss adds a smoothness and stu...
More Details →
MK-T
Makala Tenor Ukulele
-
$99
$89
X
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Makala Tenor Ukulele
MKT2105
$99.00 MSRP
$89.00
The Makala Classic line is simply the best entry-level ukulele on the market. Sound and playability usually suffer when offered at these affordab...
More Details →
Out of Stock
MK-B
Makala Baritone Ukulele
-
$109
$99
X
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Out of Stock
Makala Baritone Ukulele
MKB2105
$109.00 MSRP
$99.00
This product is temporarily unavailable online.
The Makala Classic line is simply the best entry-level ukulele on the market. Sound and playability usually suffer when offered at these affordab...
More Details →
KA-B
Satin Mahogany Baritone Ukulele
-
$159
$149
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Satin Mahogany Baritone Ukulele
KAB2006
$159.00 MSRP
$149.00
The Satin Mahogany line is Kala’s flagship collection and has become an industry standard. The traditional design is highlighted with a satin fini...
More Details →
Out of Stock
KA-SPRK-PINK
Pink Champagne Sparkle Concert Ukulele
-
$119
X
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Out of Stock
Pink Champagne Sparkle Concert Ukulele
KASPRKPINK2006
$119.00
MSRP
This product is temporarily unavailable online.
Welcome to the Roaring 2020’s! 1920 would have been jubilant to have these glittery, glamorous ukuleles! So classy—with colors like Ritzy Red, Pink...
More Details →
KA-PWC
Pacific Walnut Concert Ukulele
-
$149
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Pacific Walnut Concert Ukulele
KAPWC2006
$149.00
MSRP
The light brown body of the Pacific Walnut line is contrasted by the rich, dark brown patterns in the grain. The remarkable look created by this c...
More Details →
KA-15T
KA-15T Satin Mahogany Tenor Ukulele
-
$119
$105
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KA-15T Satin Mahogany Tenor Ukulele
KA15T2006
$119.00 MSRP
$105.00
The KA-15 Series is Kala’s flagship Mahogany collection and has become an industry standard. The traditional design is highlighted with a satin fin...
More Details →
Out of Stock
KA-TK-C-CE
Teak Tri-Top Concert Ukulele w/ Cutaway & EQ
-
$109
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Out of Stock
Teak Tri-Top Concert Ukulele w/ Cutaway & EQ
KA-TK-C-CE
$109.00
MSRP
This product is temporarily unavailable online.
Our Teak Tri-Top Ukulele Series is a striking addition to our line of affordable ukuleles. Made primarily of Teak—a tropical hardwood that has a ve...
More Details →
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At first look and listen, The Birdwatchers present as a light-hearted and accessible acoustic...
February 08, 2024
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The New Year brings inspiration for growth and change; it's the perfect time to expand...
January 11, 2024
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The Ultimate Guide To Ukulele Tonewoods
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January 04, 2024
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© 2024 KALA BRAND MUSIC CO.™
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The Revelator™
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Ukulele
All
The Revelator™
Kala® Elite USA
Kala® Metropolitan™
Contour Series
Solid Body Electric
Solid Wood
Solid Top
Americana
Travel
Exotic Wood
Mahogany
Artist Signature
Kala® Learn to Play
Novelty
Makala®
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U•BASS®
All
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Built To Brighten Your Play
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Limited Edition Koa Top U•BASS®
15th Anniversary Model Now Available
Shop Now
Beginner to Legend
As the most recognizable and trusted name in ukulele, Kala Brand Music Co.™ has more unique models to choose from than any other brand in the world! Musical icons across genres choose to play Kala instruments—Twenty One Pilots, Vance Joy, and Prince’s former bassist, Nik West, to name a few. Kala is the place where countless players got their start—from beginner to legend.
Shop All Ukulele
Handcrafted in California
The Revelator™ by Kala is a true revelation of creative ukulele design and aesthetic. Handcrafted in the Kala Brand Music Co. Lutherie Studio in Petaluma, California, The Revelator™ is an “Acoustic Anomaly”—a slim line electro-acoustic ukulele that has all of the acoustic tone and volume of a full body ukulele. The instrument is as inspiring to view as it is to play.
Shop Revelator™
Shop Beginner Ukulele Bundles
The Kala® Learn To Play Series is the perfect tool for beginners of any age to learn the ukulele. Check out some of our most popular beginner ukuleles, including the Learn To Play Ukulele Starter Kit, Mandy Harvey Signature Series Tenor, and more — there’s something here for everyone!
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MK-SS/BLK
Blacktip Soprano Shark Ukulele
-
$59
X
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Blacktip Soprano Shark Ukulele
MKSSBLK2006
$59.00
MSRP
The Makala Shark line is well-suited for casual players looking for something colorful and fun to sink their teeth into. The Shark is a terrific ...
More Details →
MK-S
Makala Soprano Ukulele
-
$59
X
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2
3
4
5
Makala Soprano Ukulele
MKS2105
$59.00
MSRP
The Makala Classic line is simply the best entry-level ukulele on the market. Sound and playability usually suffer when offered at these affordab...
More Details →
MK-SS/WHT
Great White Soprano Shark Ukulele
-
$59
X
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Great White Soprano Shark Ukulele
MKSSWHT2006
$59.00
MSRP
The Makala Shark line is well-suited for casual players looking for something colorful and fun to sink their teeth into. The Shark is a terrific ...
More Details →
MK-SD/RDBURST
Red Burst Soprano Dolphin Ukulele
-
$59
X
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Red Burst Soprano Dolphin Ukulele
MKSDRDBURST2006
$59.00
MSRP
The Makala Dolphin line is an excellent first ukulele to dive in with. The Dolphin comes in an assortment of colors with a classic look that soun...
More Details →
KALA-LTP-S
Kala Learn To Play Soprano Ukulele Starter Kit
-
$79
$75
X
Images
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7
Kala Learn To Play Soprano Ukulele Starter Kit
KALALTPS2105
$79.00 MSRP
$75.00
Our classic beginner ukulele, the Kala Learn to Play Ukulele Starter Kit comes with everything you need to start playing today. This pack is perfe...
More Details →
MK-S/PACK
Makala Soprano Ukulele Pack
-
$89
$79
X
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Makala Soprano Ukulele Pack
MKSPACK2105
$89.00 MSRP
$79.00
The MK-S Pack includes a Makala Classic Soprano ukulele, clip-on tuner, gig bag, and instruction pamphlet. The Makala Classic Soprano ukulele is ...
More Details →
KK-R-BLK
Kala Klipz Recharge
-
$16
X
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Kala Klipz Recharge
KK-R-BLK
$16.00
MSRP
Color
Black
Grey
White
Black
Grey
White
is backordered. We will ship it separately as soon as it arrives.
Our first rechargeable, the Kala Klipz Recharge clip-on tuner has Chromatic, Guitar, Bass, Ukulele, and Violin tuning settings to get most any stri...
More Details →
KA-15C
KA-15C Satin Mahogany Concert Ukulele
-
$99
$85
X
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KA-15C Satin Mahogany Concert Ukulele
KA15C2006
$99.00 MSRP
$85.00
The KA-15 Series is Kala’s flagship Mahogany collection and has become an industry standard. The traditional design is highlighted with a satin fin...
More Details →
KA-15S-BLK
Black Satin Mahogany Soprano Ukulele
-
$69
$65
X
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3
4
Black Satin Mahogany Soprano Ukulele
KA15SBLK2006
$69.00 MSRP
$65.00
The KA-15 Series is Kala’s flagship Mahogany collection and has become an industry standard. The traditional design is highlighted with a satin fin...
More Details →
KALA-LTP-MH
Mandy Harvey Learn To Play Signature Series Tenor Ukulele
-
$149
$139
X
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3
4
5
Mandy Harvey Learn To Play Signature Series Tenor Ukulele
KALALTPMH2006
$149.00 MSRP
$139.00
We are excited to announce the newest addition to our Learn To Play series—the Mandy Harvey Learn To Play Signature Series Tenor Ukulele!
Mandy is...
More Details →
Logo Gig Bag
-
$25
from
$17
X
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Logo Gig Bag
$24.99 MSRP
$17.00
Select Size
Soprano
Concert
Tenor
Baritone / Acoustic & 4-String U•BASS®
Soprano
Concert
Tenor
Baritone / Acoustic & 4-String U•BASS®
is backordered. We will ship it separately as soon as it arrives.
Let your ukulele know you love it by keeping it safe in a Kala Logo Gig Bag. The Logo Gig Bags have a plush, padded interior to help protect your u...
More Details →
MK-SD/PLBURST
Purple Burst Soprano Dolphin Ukulele
-
$59
X
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Purple Burst Soprano Dolphin Ukulele
MKSDPLBURST2006
$59.00
MSRP
The Makala Dolphin line is an excellent first ukulele to dive in with. The Dolphin comes in an assortment of colors with a classic look that soun...
More Details →
KA-SPRK-RED
Ritzy Red Sparkle Concert Ukulele
-
$129
$119
X
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Ritzy Red Sparkle Concert Ukulele
KASPRKRED2006
$129.00 MSRP
$119.00
Welcome to the Roaring 2020’s! 1920 would have been jubilant to have these glittery, glamorous ukuleles! So classy—with colors like Ritzy Red, Pink...
More Details →
KA-SPRK-AQUA
Rhapsody in Blue Sparkle Concert Ukulele
-
$129
$119
X
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KALA: Knowledge-Augmented Language Model Adaptation - ACL Anthology
: Knowledge-Augmented Language Model Adaptation - ACL AnthologyACL Anthology
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KALA: Knowledge-Augmented Language Model AdaptationMinki Kang,
Jinheon Baek,
Sung Ju HwangAbstractPre-trained language models (PLMs) have achieved remarkable success on various natural language understanding tasks. Simple fine-tuning of PLMs, on the other hand, might be suboptimal for domain-specific tasks because they cannot possibly cover knowledge from all domains. While adaptive pre-training of PLMs can help them obtain domain-specific knowledge, it requires a large training cost. Moreover, adaptive pre-training can harm the PLM’s performance on the downstream task by causing catastrophic forgetting of its general knowledge. To overcome such limitations of adaptive pre-training for PLM adaption, we propose a novel domain adaption framework for PLMs coined as Knowledge-Augmented Language model Adaptation (KALA), which modulates the intermediate hidden representations of PLMs with domain knowledge, consisting of entities and their relational facts. We validate the performance of our KALA on question answering and named entity recognition tasks on multiple datasets across various domains. The results show that, despite being computationally efficient, our KALA largely outperforms adaptive pre-training.Anthology ID:2022.naacl-main.379Volume:Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language TechnologiesMonth:JulyYear:2022Address:Seattle, United StatesEditors:Marine Carpuat,
Marie-Catherine de Marneffe,
Ivan Vladimir Meza RuizVenue:NAACLSIG:Publisher:Association for Computational LinguisticsNote:Pages:5144–5167Language:URL:https://aclanthology.org/2022.naacl-main.379DOI:10.18653/v1/2022.naacl-main.379Bibkey:kang-etal-2022-kalaCite (ACL):Minki Kang, Jinheon Baek, and Sung Ju Hwang. 2022. KALA: Knowledge-Augmented Language Model Adaptation. In Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, pages 5144–5167, Seattle, United States. Association for Computational Linguistics.Cite (Informal):KALA: Knowledge-Augmented Language Model Adaptation (Kang et al., NAACL 2022)Copy Citation:BibTeX
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More options…PDF:https://aclanthology.org/2022.naacl-main.379.pdfVideo: https://aclanthology.org/2022.naacl-main.379.mp4Code nardien/kalaDataCoNLL 2003, NCBI Disease, NewsQA, WNUT 2017PDF
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×BibTeXMODS XMLEndnotePreformatted@inproceedings{kang-etal-2022-kala,
title = "{KALA:} Knowledge-Augmented Language Model Adaptation",
author = "Kang, Minki and
Baek, Jinheon and
Hwang, Sung Ju",
editor = "Carpuat, Marine and
de Marneffe, Marie-Catherine and
Meza Ruiz, Ivan Vladimir",
booktitle = "Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies",
month = jul,
year = "2022",
address = "Seattle, United States",
publisher = "Association for Computational Linguistics",
url = "https://aclanthology.org/2022.naacl-main.379",
doi = "10.18653/v1/2022.naacl-main.379",
pages = "5144--5167",
abstract = "Pre-trained language models (PLMs) have achieved remarkable success on various natural language understanding tasks. Simple fine-tuning of PLMs, on the other hand, might be suboptimal for domain-specific tasks because they cannot possibly cover knowledge from all domains. While adaptive pre-training of PLMs can help them obtain domain-specific knowledge, it requires a large training cost. Moreover, adaptive pre-training can harm the PLM{'}s performance on the downstream task by causing catastrophic forgetting of its general knowledge. To overcome such limitations of adaptive pre-training for PLM adaption, we propose a novel domain adaption framework for PLMs coined as Knowledge-Augmented Language model Adaptation (KALA), which modulates the intermediate hidden representations of PLMs with domain knowledge, consisting of entities and their relational facts. We validate the performance of our KALA on question answering and named entity recognition tasks on multiple datasets across various domains. The results show that, despite being computationally efficient, our KALA largely outperforms adaptive pre-training.",
}
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Copy to Clipboard%0 Conference Proceedings
%T KALA: Knowledge-Augmented Language Model Adaptation
%A Kang, Minki
%A Baek, Jinheon
%A Hwang, Sung Ju
%Y Carpuat, Marine
%Y de Marneffe, Marie-Catherine
%Y Meza Ruiz, Ivan Vladimir
%S Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies
%D 2022
%8 July
%I Association for Computational Linguistics
%C Seattle, United States
%F kang-etal-2022-kala
%X Pre-trained language models (PLMs) have achieved remarkable success on various natural language understanding tasks. Simple fine-tuning of PLMs, on the other hand, might be suboptimal for domain-specific tasks because they cannot possibly cover knowledge from all domains. While adaptive pre-training of PLMs can help them obtain domain-specific knowledge, it requires a large training cost. Moreover, adaptive pre-training can harm the PLM’s performance on the downstream task by causing catastrophic forgetting of its general knowledge. To overcome such limitations of adaptive pre-training for PLM adaption, we propose a novel domain adaption framework for PLMs coined as Knowledge-Augmented Language model Adaptation (KALA), which modulates the intermediate hidden representations of PLMs with domain knowledge, consisting of entities and their relational facts. We validate the performance of our KALA on question answering and named entity recognition tasks on multiple datasets across various domains. The results show that, despite being computationally efficient, our KALA largely outperforms adaptive pre-training.
%R 10.18653/v1/2022.naacl-main.379
%U https://aclanthology.org/2022.naacl-main.379
%U https://doi.org/10.18653/v1/2022.naacl-main.379
%P 5144-5167
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Copy to ClipboardMarkdown (Informal)[KALA: Knowledge-Augmented Language Model Adaptation](https://aclanthology.org/2022.naacl-main.379) (Kang et al., NAACL 2022)KALA: Knowledge-Augmented Language Model Adaptation (Kang et al., NAACL 2022)ACLMinki Kang, Jinheon Baek, and Sung Ju Hwang. 2022. KALA: Knowledge-Augmented Language Model Adaptation. In Proceedings of the 2022 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, pages 5144–5167, Seattle, United States. Association for Computational Linguistics.Copy Markdown to Clipboard
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ACL materials are Copyright © 1963–2024 ACL; other materials are copyrighted by their respective copyright holders. Materials prior to 2016 here are licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 International License. Permission is granted to make copies for the purposes of teaching and research. Materials published in or after 2016 are licensed on a Creative Commons Attribution 4.0 International License.The ACL Anthology is managed and built by the ACL Anthology team of volunteers.Site last built on 07 March 2024 at 01:07 UTC with commit 63db20f.
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About Kala Brand Music Co.™
California Owned. Hawaii Inspired.
Who We Are
Kala Brand Music Co.™ is the world’s most-popular ukulele brand and the founder of the Original U•BASS®, family-owned and operated in the sunny Northern California city of Petaluma.
Kala is home to the most diverse catalog of ukuleles in history, with a wide variety of offerings in sizes, styles and tonewoods, all bound by a singular quality and creative vision.
We are the brand of choice for artists like Vance Joy, Twenty One Pilots, mxmtoon, Walk Off the Earth, and dodie, with instruments sold and enjoyed in over 50 countries around the globe.
Our Story
A California-born & raised musician, Mike Upton first fell in love with the ‘ukulele and its uniquely beautiful craftsmanship and tone while living and working in Hawaii in the 1990s. But for all their immense potential for more widespread use and enjoyment outside the islands, at the time he could find very few options available between the high-cost, artisan ukulele makers and cheap, poorly-built toys.
After returning to his hometown of Petaluma, California, Mike founded Kala Ukulele to begin to design and build affordable ukuleles to make the instrument he loved more widely accessible. The first team of Kala sales and instrument techs was formed in 2005, working out of a converted chicken hatchery. With a keen sense of design and quality, Kala was able to rapidly expand its production and distribution to a national scale, emerging as a leading name in ukulele during a renaissance decade of boutique interest in the instrument throughout indie music circles in the United States, Canada, and England.
From the KA-15, the satin mahogany series that became the brand’s early flagship, Kala was also able to turn heads with an expanding catalog of sizes and internationally-sourced woods previously uncommon to the ukulele and now synonymous with Kala, such as Pacific Walnut, Exotic Mahogany, Striped Ebony, Flame Maple, and Ziricote.
In 2009, we made waves in the ukulele and bass communities alike with the introduction of the U•BASS®, the world’s first ukulele bass, a concept that came from the discovery of the massive tonal capabilities of thick, lightweight rubber strings atop a baritone ukulele body. After some early support and endorsements from venerated players in the world of bass like Bakithi Kumalo, Abraham Laboriel Sr., and Hutch Hutchinson, the U•BASS® developed a reputation as a small, but mighty powerhouse in the future of bass. You can see our expanded U•BASS® catalog here.
Just a decade into Kala’s business, the global levels of awareness and interest in the ukulele had reached an all-time high, with breakthrough pop acts like Vance Joy, Twenty One Pilots, Walk Off the Earth, and Eddie Vedder giving the instrument unparalleled global visibility.
In 2013, to better meet the needs of brand new players and schools on a budget, Kala finalized and released The Waterman: an all-weather, plastic ukulele inspired by the 1950s Maccaferri ukuleles. A few years following its launch, Kala undertook a massive donation initiative of over 10,000+ Waterman to schools throughout the country to seed and support music programs. The Waterman earned a fast reputation for playability and durability, and to this day remains the most commonly used ukulele in American classrooms.
After the widespread success of Kala’s imported instruments, Mike was able to realize a lifelong dream in 2015 by forming a team of local luthiers and builders to introduce the first USA-Made varieties of Kala Ukuleles, branded as our Kala® Elite USA Series. Taylor Guitar helped to provide Kala with our first side-bending machines. Kala Elite Ukuleles were quickly followed by the creation of the California U•BASS®, a solid body counterpart to the then-established success of the Acoustic-Electric U•BASS®. Hawaiian Koa, Honduran Mahogany, and Sitka Spruce have been among our most successful tonewoods for Kala Elite instruments.
The 2010’s also saw Kala introduce our first artist signature series instruments for artists like Nik West, Bakithi Kumalo, and America’s Got Talent’s Mandy Harvey with her own Learn to Play Tenor. Since 2020, Kala has followed these releases with the Elvis Signature Learn To Play Series and an Artist Signature ukulele for the Oakland-based songwriter mxmtoon.
Today, Kala enjoys a phenomenally supportive base of players internationally and the hard-earned status of the world’s best-selling ukulele brand. With our 15th Anniversary just behind us, Kala remains just as committed to our original values today as we were in our first year: player-ready quality, affordable prices, and inspired instrument design.
“About Us” Mini FAQ
How do you pronounce “Kala”
“Kala” is pronounced / k.ah.lah /. It rhymes with “koala.”
What does “Kala” mean?
“Kala” is a Hawaiian word meaning “good fortune.” However, like many Hawaiian words, it historically has had many different meanings and uses.
Where is Kala located?
Kala was founded and is based today out of the city of Petaluma, California, just an hour north of San Francisco. We also have warehouses in Honolulu, HI and Ashland, VA.
What does Kala do?
We design and manufacture instruments, specializing in the ukulele and the U•BASS®. We also dabble in the cajón and unique variations of acoustic guitar.
Where are Kala instruments made?
All Kala models are designed in California and manufactured by teams in select locations throughout the globe, depending on the model; we have a variety of products manufactured in China, Indonesia, Portugal, Vietnam, and India. The Kala® Elite USA Series and California U•BASS® Series are built here in the United States.
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© 2024 KALA BRAND MUSIC CO.™
1129 Industrial Ave, Suite 204, Petaluma, CA 94952
(707) 775-4073
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Kala Ukulele
If you’re looking for your first ukulele or if you’ve been playing for years, there is a Kala for everyone. The Kala line continues to grow and expand with ukulele in any price range. Known for high-quality ukulele that sound great, we offer many styles, finishes, and woods to choose from.
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© 2024 KALA BRAND MUSIC CO.™
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Kala
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又名: 卡拉卡拉帮
表演者:
M.I.A.
流派: 说唱
专辑类型: 专辑
介质: Audio CD
发行时间: 2007-08-21
出版者: Interscope Records
唱片数: 1
条形码: 0634904028121
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简介
· · · · · ·
M.I.A.的背景特殊，出生于英国，父亲是革命组织创办人，却也因此她流亡于斯里兰卡成为难民。也许是这般的际遇，让M.I.A.的作品有了深度的世界观，在2004年初试啼声的Mixtape作品《Piracy Funds Terrorism》便引起乐坛一阵骚动，来年加入XL厂牌的正式专辑《Arular》，迅速夺下全美电子榜季军／热门潜力榜Top15／独立榜Top16！更吸引嘻哈教母蜜希艾莉特、旷课乐小公主席亚拉、当红制作大佬Timbaland等，热情邀约M.I.A.在其畅销作品中轧上一角！ 此回M.I.A.再度与制作人Swith与Diplo合作全新大碟《Kala》，三个人在世界各角落找寻新概念与灵感；她唱出了第三世界人民心中急切的自由渴望，奋力一搏争取向往事物的生活态度。首波主打〈Boyz〉融入印度手鼓、Soca、嘻哈与舞曲节拍音源，荣登目前最夯的舞池...
(展开全部)
M.I.A.的背景特殊，出生于英国，父亲是革命组织创办人，却也因此她流亡于斯里兰卡成为难民。也许是这般的际遇，让M.I.A.的作品有了深度的世界观，在2004年初试啼声的Mixtape作品《Piracy Funds Terrorism》便引起乐坛一阵骚动，来年加入XL厂牌的正式专辑《Arular》，迅速夺下全美电子榜季军／热门潜力榜Top15／独立榜Top16！更吸引嘻哈教母蜜希艾莉特、旷课乐小公主席亚拉、当红制作大佬Timbaland等，热情邀约M.I.A.在其畅销作品中轧上一角！ 此回M.I.A.再度与制作人Swith与Diplo合作全新大碟《Kala》，三个人在世界各角落找寻新概念与灵感；她唱出了第三世界人民心中急切的自由渴望，奋力一搏争取向往事物的生活态度。首波主打〈Boyz〉融入印度手鼓、Soca、嘻哈与舞曲节拍音源，荣登目前最夯的舞池大热曲！〈20 Dollar〉旋律部份取样英伦大团New Order畅销曲〈Blue Monday〉，歌词部份则混入美国另类乐团The Pixies经典〈Where Is My Mind?〉；巧妙混搭庞克团The Clash和饶舌团体Wreckx-N-Effect的〈Paper Planes〉呈现第三世界生活态度；末曲〈Come Around〉则是和「嘻哈排行冠军制造机」Timbaland合力演出！Ragga狂野节奏（Dancehall + Hip Hop）＋印度宝莱坞异国情调＋前卫新潮街头风格…「这是一张令人觉醒的专辑」M.I.A.如是说。M.I.A.街头酷妹的独特形象、令人惊喜连连的音乐态度…你还在等什么？快点踏上M.I.A.的另类街头，一起加入她的Kala卡拉帮吧！
曲目
· · · · · ·
1. Bamboo Banga2. Bird Flu3. Boyz4. Jimmy5. Hussel6. Mango Pickle Down River7. 20 Dollar8. World Town9. Turn10. XR211. Paper Planes12. Come Around
喜欢听"Kala"的人也喜欢的唱片
· · · · · ·
Arular
9.0
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9.0
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9.5
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Homogenic
9.2
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9.3
我来说两句
短评
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Dxxm☠️
2016-12-19 18:46:33
这张玩得还不错,以至于当时我们街区的小孩都喜欢把Paper Planes当童谣唱
0
有用
齊克斯尼力佐飛
2011-07-13 10:25:28
这样的电子嘻哈我倒是很容易就接受了。
1
有用
RIC
2011-10-28 06:53:52
全新的体验
1
有用
Song³
2013-04-13 01:02:33
Paper Planes.
3
有用
川总
2012-05-28 11:18:51
高密度高能量
0
有用
momo
2024-01-16 12:21:09
重庆
有机结合
0
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untureeei_o
2024-03-04 18:27:48
德国
豆瓣为什么莫名其妙删标记？
0
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s
2024-02-23 11:39:31
广东
@2024-01-16 11:30:18
0
有用
fotns
2024-02-03 04:23:46
四川
爆星
0
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阿煩
2024-01-31 17:18:20
安徽
A，牛大了
> 更多短评 1122 条
我要写乐评
Kala的乐评 · · · · · ·
( 全部 10 条 )
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好友
DLL@baidu
2015-05-03 21:46:37
Going After a Song - "Bamboo Banga"
"Bamboo Banga"是Hip Hop近20年来最重要也最正确趋势交汇的产物： Outkast的Alt摇滚式Hip Hop以及Timbaland的世界风Hip Hop； 但M.I.A.本人的初衷应该要单纯的多：punk， “Roadrunner roadrunner， going hundred miles per hour” 出自经典的前朋克"Roadrunner"，如果你和我...
(展开)
69
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SEAZO
2019-01-31 21:26:03
第三世界之海的女飞贼
不可否认M.I.A音乐元素里避不开的政治元素，让她的音乐人格更加飞扬跋扈 ，如果M.I.A是个普通的斯里兰卡女孩，或许她不会被美国拒签，这些命运一般的事物更像是她应该拥有的天赋，是她多元音乐拼图里的一块。 我更加确信，人生履历会明显地影响艺术创作者，所以M.I.A的音乐必然...
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21
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爱地人
2007-12-03 16:59:57
吉米吉米，嘻哈嘻哈
艺人：M.I.A. 专辑：Kala 发行时间：2007/8/20 厂牌：XL 评分：★★★★ 听过这张M.I.A.的新作《Kala》，你就会发现去年Fergie发行的首张单飞专辑，有多么多么的发育不良，俨然就是一张Ketty版的Hip-Hop专辑，粉嘟嘟的颜色倒很是好看，只不过在嘻哈的江湖，还是纯属那种...
(展开)
28
8
13回应
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.浮砾戈斯塔
2008-03-30 11:07:57
触电后摇摆
出现在2007，偶遇在2008。 在准备写2007所喜欢的10大英文唱片的时候，遇到了这张专辑被“滚石杂志”在07年选为最好的50张专辑的第一位的《Kala》。 在游戏的时候，听着那首让人神魂颠倒的Jimmy. 不断地在“吉米、吉米，来吧、来吧！” 让DOTA中的我耍起了虚空漫步，被队员...
(展开)
7
1
0回应
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dawnfair
2008-01-06 07:15:28
M.I.A
M.I.A一位来自斯里兰卡的女歌手 大胆叛逆 有冒险精神 甚至有点疯狂 亲身经历过内战和暴力袭击事件 因为父亲参与一个叫泰米尔猛虎的分离组织 美国曾禁止她入境 整张专辑记录了M.I.A从印度到特立尼达 纽约 伦敦 巴尔的摩过去生活的一年 十分国际化的声音 HIP-HOP风格里混合着她...
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4
1
2回应
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SanSan
2009-05-11 20:42:23
在火车顶跳起土著舞
那两声枪响，墨西哥式的开场，实在让人耳目一新，格莱美上顶着个大肚子，穿着可爱的点点裙，好似一颗鸡蛋，在那边和两个黑人一起唱paper planes，酷毙的女人。 在贫民窟的百万富翁里面，火车上那一段又是这首歌，我靠，太赞了，好似她另一手bird flu一样，让人high到不行。 ...
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8
1
5回应
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Lance
2015-08-30 14:12:08
One Hell Of a Golden Touch
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1
0回应
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风子
2011-12-03 21:00:02
又带来了一架高能量的政治+另类舞曲轰炸机。
本名Mathangi Arulpragasam的英国女人M.I.A.一出道就因其出身背景而倍受关注：父母都是斯里兰卡人，而父亲是泰米尔猛虎分裂组织战士。2年前她的首张个人专辑《Arular》被喻为近来最具政治意识的杰作而大受好评，如今，这位身居伦敦的泰米尔女战士再次登场，又带来了一架高能量...
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青蛙
2011-04-12 13:47:22
妖妖武 DL
f26808528a 豆娘说，评论必须长。 豆娘说，评论必须长。 豆娘说，评论必须长。 豆娘说，评论必须长。 豆娘说，评论必须长。 豆娘说，评论必须长。 豆娘说，评论必须长。 豆娘说，评论必须长。 如果过期了可以提醒我续期
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2
3
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Eccentricity
2009-02-04 01:06:22
super addictive
因为最近看'贫民窟的百万富翁'(slumdog millionaire), 听到了M.I.A. 的paper planes被作为背景音乐,超级有感觉.于是找了整张专辑来听. 音乐很古怪, 歌词超直接, 但最重要的是, 听了不是一般的上瘾!
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"Kala"的论坛
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就是很到位很牛逼来自pony
1 回应
2013-09-06 15:14:28
喜欢PAPER PLANES来自ki.wa
9 回应
2013-06-23 14:38:04
歌词在此来自ⒹⓎ
1 回应
2012-09-15 10:48:52
居然“翻唱”了Pixies的Where is my mind来自wwei
3 回应
2012-07-11 22:14:36
Hussel 现场视频一则来自玛丽隔壁的小彼得
2 回应
2010-09-08 10:24:32
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Kala Guitars
We’ve spent a lot of time perfecting our guitars to make sure they stand out in the big world of acoustic guitar. Each one has a well-thought-out purpose and is unique, performance-oriented, and enjoyable for any player. From the small but mighty Guitarlele, to the affordable Classical Student Guitars that come in two sizes, and to the powerful rich-sounding Parlor Guitar - we create guitars the way we create ukuleles—built to last. These guitars all have superior sound and affordability. With each new model - you truly get more than what you pay for. Browse through our selection and see which guitar fits your style best!
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Travel Guitars
1
model
from $339.00
Classical Student Guitars
2
models
from $169.00
Parlor Guitars
1
model
from $349.00
Orchestra Mini Guitars
2
models
from $399.00
Thinline Guitars
2
models
from $379.00
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© 2024 KALA BRAND MUSIC CO.™
1129 Industrial Ave, Suite 204, Petaluma, CA 94952
(707) 775-4073
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